™Why a 4-Billion-Point Kaggle Dataset Still Couldn't Beat Chance — Ian Quigley, Leash Bio (Latent Space)
Latent Space podcast episode of Oct 14, 2026, 1:49:56. The host interviews Ian Quigley of Leash Bio on how DNA-encoded libraries produce high-throughput protein–small-molecule interaction data; the BELKA Kaggle competition (about 4B measurements, ~2,000 teams) where no team beat chance on an unseen
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Introduction: Ian Quigley and Leash Bio
How DNA-encoded libraries work
Barcodes and controls to catch DNA-binding false positives
Designing the BELKA Kaggle competition: ~4B measurements, hidden evaluations
What the Kaggle results taught: no team beat chance among ~2,000
Clever Hans: predicting a molecule's chemist from its structure
Language models and the scientific-reasoning sandbox Minos
From DEL hits to mouse PK/PD in six months on an inflammation program
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